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dc.contributor.authorJohansen, Silje
dc.contributor.authorBlomberg, Bjørn
dc.contributor.authorVo, Anh Khoi
dc.contributor.authorWendelbo, Øystein
dc.contributor.authorReikvam, Håkon
dc.date.accessioned2023-01-20T12:24:26Z
dc.date.available2023-01-20T12:24:26Z
dc.date.created2022-09-28T11:24:20Z
dc.date.issued2022
dc.identifier.citationCytotherapy. 2022, 24 (12), 1190-1194.en_US
dc.identifier.issn1465-3249
dc.identifier.urihttps://hdl.handle.net/11250/3044941
dc.descriptionThis is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en_US
dc.description.abstractBackground aims: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for patients with hematological malignancies; however, allo-HSCT does not come without the cost of treatmentrelated morbidity and mortality. Early detection of risk factors could be helpful in identifying patients who could benefit from early interventions. Many patients gain weight during the allo-HSCT treatment, although little is known about the impact of weight gain. Methods: Weight gain in 146 consecutively enrolled adult patients undergoing allo-HSCT was explored. Results: In total, 141 patients (97%) gained weight along the course of allo-HSCT. Median weight increase was 4.8 kg (range 0.016.1 kg), with median increase in body weight 6.5% (range 0.0%30.8%). Maximum weight increase was observed at day +7 (range day 8, +44). Weight gain was associated with increased incidence of acute graft-versus-host disease. Patients with weight gain >10% had a significantly greater 5-year mortality compared with those with lower weight gain (P = 0.031, rank sum test). Conclusions: Weight gain is a simple variable with the ability to provide prognostic information for patients undergoing allo-HSCT.en_US
dc.language.isoengen_US
dc.publisherISIS Medical Mediaen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectweight increaseen_US
dc.subjectgraft versus host diseaseen_US
dc.subjectCapillary leak syndromeen_US
dc.subjectallogeneic stem cell transplantationen_US
dc.titleWeight gain during treatment course of allogenic hematopoietic stem cell transplantation in patients with hematological malignancies affects treatment outcomeen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2022 International Society for Cell & Gene Therapy. Published by Elsevier Incen_US
dc.source.pagenumber1190-1194en_US
dc.source.volume24en_US
dc.source.journalCytotherapyen_US
dc.source.issue12en_US
dc.identifier.doi10.1016/j.jcyt.2022.08.006
dc.identifier.cristin2056274
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal