Evaluating routine blood tests according to clinical symptoms and diagnostic criteria in individuals with myalgic encephalomyelitis/chronic fatigue syndrome
dc.contributor.author | Baklund, Ingrid H. | |
dc.contributor.author | Dammen, Toril | |
dc.contributor.author | Moum, Torbjørn Åge | |
dc.contributor.author | Kristiansen, Wenche | |
dc.contributor.author | Duarte, Daysi Sosa | |
dc.contributor.author | Castro Marrero, Jesus | |
dc.contributor.author | Helland, Ingrid Bergliot | |
dc.contributor.author | Strand, Elin Bolle | |
dc.date.accessioned | 2021-10-12T08:09:34Z | |
dc.date.available | 2021-10-12T08:09:34Z | |
dc.date.created | 2021-09-22T09:30:04Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Journal of Clinical Medicine. 2021, 10 (14), 1-14. | en_US |
dc.identifier.issn | 2077-0383 | |
dc.identifier.uri | https://hdl.handle.net/11250/2789164 | |
dc.description.abstract | There is a lack of research regarding blood tests within individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and between patients and healthy controls. We aimed to compare results of routine blood tests between patients and healthy controls. Data from 149 patients diagnosed with ME/CFS based on clinical and psychiatric evaluation as well as on the DePaul Symptom Questionnaire, and data from 264 healthy controls recruited from blood donors were compared. One-way ANCOVA was conducted to examine differences between ME/CFS patients and healthy controls, adjusting for age and gender. Patients had higher sedimentation rate (mean difference: 1.38, 95% CI: 0.045 to 2.714), leukocytes (mean difference: 0.59, 95% CI: 0.248 to 0.932), lymphocytes (mean difference: 0.27, 95% CI: 0.145 to 0.395), neutrophils (mean difference: 0.34, 95% CI: 0.0 89 to 0.591), monocytes (mean difference: 0.34, 95% CI: 0.309 to 0.371), ferritin (mean difference: 28.13, 95% CI: −1.41 to 57.672), vitamin B12 (mean difference: 83.43, 95% CI: 62.89 to 124.211), calcium (mean difference: 0.02, 95% CI: −0.02 to 0.06), alanine transaminase (mean difference: 3.30, 95% CI: −1.37 to -7.971), low-density lipoproteins (mean difference: 0.45, 95% CI: 0.104 to 0.796), and total proteins (mean difference: 1.53, 95% CI: −0.945 to 4.005) than control subjects. The patients had lower potassium levels (mean difference: 0.11, 95% CI: 0.056 to 0.164), creatinine (mean difference: 2.60, 95% CI: 0.126 to 5.074) and creatine kinase (CK) (mean difference: 37.57, 95% CI: −0.282 to 75.422) compared to the healthy controls. Lower CK and creatinine levels may suggest muscle damage and metabolic abnormalities in ME/CFS patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.subject | creatine kinase | en_US |
dc.subject | creatinine | en_US |
dc.subject | functional status | en_US |
dc.subject | diagnostic criteria | en_US |
dc.subject | routine blood tests | en_US |
dc.subject | myalgic encephalomyelitis/chronic fatigue syndrome | en_US |
dc.subject | ME | en_US |
dc.subject | ME/CFS | en_US |
dc.title | Evaluating routine blood tests according to clinical symptoms and diagnostic criteria in individuals with myalgic encephalomyelitis/chronic fatigue syndrome | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Open Access | en_US |
dc.source.pagenumber | 1-14 | en_US |
dc.source.volume | 10 | en_US |
dc.source.journal | Journal of Clinical Medicine | en_US |
dc.source.issue | 14 | en_US |
dc.identifier.doi | 10.3390/jcm10143105 | |
dc.identifier.cristin | 1936933 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 |
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