Browsing VID:Open by Subject "variants of uncertain significance"
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Functional analyses of rare germline missense BRCA1 variants located within and outside protein domains with known functions
(Peer reviewed; Journal article, 2023)The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). ...